The most common and most likely answer to this crossword clue is the 8 letter word COCKEYED
I've seen this crossword clue in The Daily Telegraph
C
O
C
K
E
Y
E
D
Buddy explains!
The straight part
We know that "at an angle" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case at an angle = cockeyed.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does COCKEYED mean?
COCKEYED adjective- Having both eyes oriented inward, cross-eyed.
- Crooked or askew.
- Absurd, silly, or stupid; usually used in reference to ideas rather than people.
- Drunk.