Cryptic crossword clue
Bit of a boob, perhaps, if is back on ecstasy 8

The most common and most likely answer to this crossword clue is the 8 letter word SILICONE

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "Bit of a boob, perhaps" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case bit of a boob, perhaps = silicone.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SILICONE mean?

SILICONE noun
  1. Any of a class of inert, semi-inorganic polymeric compounds (polysiloxanes), that have a wide range of thermal stability and extreme water repellence, used in a very wide range of industrial applications, and in prosthetic replacements for body parts.

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