The most common and most likely answer to this crossword clue is the 6 letter word TWINGE
I've seen this crossword clue in Financial Times
T
W
I
N
G
E
More clues leading to the result TWINGE
- Pair with say back pain
- Colour slightly covering wife’s stab of pain
- Twisted cord around middle of fingers. Result: sharp pain
- Left winger’s disguising sudden pain
- Bit of pain in match, say, twisting
- Pang suffered by one of two, for example, on rising
- Bit of a pain to get disguised to secure victory
- Sudden pain, double gets halved
- The heart being lost with side in pain
- Pair, say, up in pain
Buddy explains!

The straight part
We know that "Bit of pain" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case bit of pain = twinge.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TWINGE mean?
TWINGE noun- A pinch; a tweak; a twitch.
- A sudden sharp pain.
- To pull with a twitch; to pinch; to tweak.
- To affect with a sharp, sudden pain; to torment with pinching or sharp pains.
- To have a sudden, sharp, local pain, like a twitch; to suffer a keen, darting, or shooting pain.