Cryptic crossword clue
Blocks in east M51 — it’s a stinker being caught there 6

The most common and most likely answer to this crossword clue is the 6 letter word EMBOLI

E
M
B
O
L
I

Buddy explains!

The straight part
We know that "Blocks" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case blocks = emboli.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EMBOLI mean?

EMBOLI noun
  1. An obstruction causing an embolism: a blood clot, air bubble or other matter carried by the bloodstream and causing a blockage or occlusion of a blood vessel.
  2. The structure on the end of the palp of male arachnids which contains the opening to the ejaculatory duct.

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