The most common and most likely answer to this crossword clue is the 2 plus 5 letter word GO SPARE
I've seen this crossword clue in The Times
G
O
S
P
A
R
E
More clues leading to the result GO SPARE
- Son and dad, covered in blood, become furious
- Become angry seeing what bull might do around resort?
- Blow up a game reserve
- Be unused, perhaps, to rage
- Get very upset, with health resort bathed in blood
- Be unused and become furious
- Water supply in blood, lose it!
- Hugo’s parents about to hit the roof
- See red and green box by front of embassy
- Hit the roof, bath covered in blood
Buddy explains!

The straight part
We know that "Blow up" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case blow up = go spare.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.