Cryptic crossword clue
Bone clusters of which human has two, fish one 5

The most common and most likely answer to this crossword clue is the 5 letter word CARPI

I've seen this crossword clue in The Guardian
C
A
R
P
I

Buddy explains!

The straight part
We know that "Bone clusters" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case bone clusters = carpi.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CARPI mean?

CARPI noun
  1. The group of bones that make up the wrist.

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