Cryptic crossword clue
Bones in fish irritate initially 5

The most common and most likely answer to this crossword clue is the 5 letter word CARPI

C
A
R
P
I

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CARPI mean?

CARPI noun
  1. The group of bones that make up the wrist.

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