The most common and most likely answer to this crossword clue is the 6 letter word EXODUS
I've seen this crossword clue in Financial Times
E
X
O
D
U
S
More clues leading to the result EXODUS
- Book is a great departure
- Journalist wraps up neat American book
- Book flight
- Endless dust on old, old book of the Bible
- Book used curious game symbols inside
- . Migration of deer going north’s protected crossing America
- Book where old puzzle, two- thirds finished, turned up
- Former love meets American aboard Delta flight
- Used at sea to carry ten over in mass migration
- Leaving old cheat to back American
Buddy explains!
The straight part
We know that "Book" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case book = exodus.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does EXODUS mean?
EXODUS noun- A sudden departure of a large number of people.
- To depart from a place in a large group.