Cryptic crossword clue
Born to die, holy woman is the most demanding 8

The most common and most likely answer to this crossword clue is the 8 letter word NEEDIEST

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NEEDIEST mean?

NEEDIEST adjective
  1. In need; poor.
  2. Desiring constant affirmation; lacking self-confidence.
  3. Needful; necessary.

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