Cryptic crossword clue
Bother in big house having a plant with narcotic properties 10

The most common and most likely answer to this crossword clue is the 10 letter word MANDRAGORA

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "plant with narcotic properties" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case plant with narcotic properties = mandragora.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MANDRAGORA mean?

MANDRAGORA noun
  1. Mandrake (genus Mandragora); often specifically mandrake root, traditionally used as a narcotic.
  2. A kind of tiny dragon immune to fire.

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