Cryptic crossword clue
Boxers may get sick of this underworld character

The most common and most likely answer to this crossword clue is the 9 letter word DISTEMPER

I've seen this crossword clue in The Times
D
I
S
T
E
M
P
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Buddy explains!

The straight part
We know that "Boxers may get sick of this" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case boxers may get sick of this = distemper.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DISTEMPER mean?

DISTEMPER noun
  1. A viral disease of animals, such as dogs and cats, characterised by fever, coughing and catarrh.
  2. A disorder of the humours of the body; a disease.
  3. A glue-based paint.
  4. A painting produced with this kind of paint.
DISTEMPER verb
  1. To temper or mix unduly; to make disproportionate; to change the due proportions of.
  2. To derange the functions of, whether bodily, mental, or spiritual; to disorder; to disease.
  3. To deprive of temper or moderation; to disturb; to ruffle; to make disaffected, ill-humoured, or malignant.
  4. To intoxicate.
  5. To paint using distemper.
  6. To mix (colours) in the way of distemper.

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