Cryptic crossword clue
Break up resistance fighting with doom all around 11

The most common and most likely answer to this crossword clue is the 11 letter word FRACTIONATE

F
R
A
C
T
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N
A
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E

Buddy explains!

The straight part
We know that "Break" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case break = fractionate.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FRACTIONATE mean?

FRACTIONATE verb
  1. To separate (a mixture) into its individual constituents by exploiting differences in some chemical or physical property, such as boiling point, particle size, solubility etc.
  2. To divide each plaintext symbol into several ciphertext symbols as a preliminary stage of encryption.
  3. To use the technique of fractionation in hypnosis.

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