Cryptic crossword clue
Breed with nympho, one frequently on course 8

The most common and most likely answer to this crossword clue is the 8 letter word RACEGOER

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Buddy explains!

The straight part
We know that "one frequently on course" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one frequently on course = racegoer.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RACEGOER mean?

RACEGOER noun
  1. One who attends horse races or dog races.

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