Cryptic crossword clue
Brian Boru causing irritation?

The most common and most likely answer to this crossword clue is the 6 letter word IRKING

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "causing irritation?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case causing irritation? = irking.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does IRKING mean?

IRKING verb
  1. To irritate; annoy; bother

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