Cryptic crossword clue
Bridge player employed by an ad firm's affected by a genetic abnormality 8

The most common and most likely answer to this crossword clue is the 8 letter word DWARFISM

D
W
A
R
F
I
S
M

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The straight part
We know that "genetic abnormality" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case genetic abnormality = dwarfism.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DWARFISM mean?

DWARFISM noun
  1. The condition of being a dwarf.

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