Cryptic crossword clue
Brute and villain played on unknown weakness 13

The most common and most likely answer to this crossword clue is the 13 letter word VULNERABILITY

I've seen this crossword clue in The Daily Telegraph
V
U
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N
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A
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Buddy explains!

The straight part
We know that "weakness" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case weakness = vulnerability.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does VULNERABILITY mean?

VULNERABILITY noun
  1. Susceptibility to attack or injury; the state or condition of being weak or poorly defended.
  2. A specific weakness in the protections or defences surrounding someone or something.
  3. A weakness which allows an attacker to reduce a system's security

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