Cryptic crossword clue
Buddhist rejects her innermost essence as she is trying to find peace 8

The most common and most likely answer to this crossword clue is the 8 letter word MEDIATOR

M
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Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MEDIATOR mean?

MEDIATOR noun
  1. One who negotiates between parties seeking mutual agreement.
  2. A chemical substance transmitting information to a targeted cell.

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