Cryptic crossword clue
Buffoonery of liar had Queen troubled 12

The most common and most likely answer to this crossword clue is the 12 letter word HARLEQUINADE

I've seen this crossword clue in The Daily Telegraph
H
A
R
L
E
Q
U
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A
D
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Buddy explains!

The straight part
We know that "Buffoonery" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case buffoonery = harlequinade.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HARLEQUINADE mean?

HARLEQUINADE noun
  1. A pantomime-like comedy featuring the harlequin or clown.
  2. Any comical or fantastical procedure or playfulness.

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