The most common and most likely answer to this crossword clue is the 8 letter word INTERSEX
I've seen this crossword clue in Financial Times
I
N
T
E
R
S
E
X
Buddy explains!
The straight part
We know that "between male and female" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case between male and female = intersex.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.