Cryptic crossword clue
Buzz, possibly, from opiate man supplemented with three rounds gone

The most common and most likely answer to this crossword clue is the 12 letter word ONOMATOPOEIA

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "Buzz, possibly" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case buzz, possibly = onomatopoeia.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ONOMATOPOEIA mean?

ONOMATOPOEIA noun
  1. The property of a word of sounding like what it represents.
  2. A word that sounds like what it represents, such as "gurgle" or "hiss".
  3. The use of language whose sound imitates that which it names.

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