Cryptic crossword clue
By all conclusions, subject far too challenging for Neanderthal 4

The most common and most likely answer to this crossword clue is the 4 letter word TROG

I've seen this crossword clue in The Guardian
T
R
O
G

Buddy explains!

The straight part
We know that "Neanderthal" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case neanderthal = trog.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TROG mean?

TROG noun
  1. A hooligan, lout.
TROG verb
  1. To walk laboriously; to trudge.

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