The most common and most likely answer to this crossword clue is the 4 letter word ROME
I've seen this crossword clue in The Sunday Telegraph
R
O
M
E
More clues leading to the result ROME
- Hear tramp in capital city.
- Part of Cairo, metropolitan capital
- Reportedly wander round capital
- Told to wander about capital
- Chaplain dropped plate in church
- More bucks for the city
- Last love’s lost by lover boy in this city
- Travel announcement in capital
- Lover’s lost love in European capital
- City church abandoning
Buddy explains!
The straight part
We know that "destination in Italy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case destination in italy = rome.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.