Cryptic crossword clue
Cadaverous state I aim at once to alter 10

The most common and most likely answer to this crossword clue is the 10 letter word EMACIATION

I've seen this crossword clue in The Times
E
M
A
C
I
A
T
I
O
N

Buddy explains!

The straight part
We know that "Cadaverous state" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cadaverous state = emaciation.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EMACIATION mean?

EMACIATION noun
  1. The act of making very lean.
  2. The state of being emaciated or reduced to excessive leanness; an excessively lean condition.

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