Cryptic crossword clue
Calamitous stage direction not potentially adroit for development 8

The most common and most likely answer to this crossword clue is the 8 letter word GENETICS

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Buddy explains!

The straight part
We know that "development" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case development = genetics.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GENETICS mean?

GENETICS noun
  1. The branch of biology that deals with the transmission and variation of inherited characteristics, in particular chromosomes and DNA.
  2. The genetic makeup of a specific individual or species.

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