Cryptic crossword clue
Calculus marker 6

The most common and most likely answer to this crossword clue is the 6 letter word PLAQUE

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The straight part
We know that "Calculus/marker" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case calculus/marker = plaque.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PLAQUE mean?

PLAQUE noun
  1. Any flat, thin piece of clay, ivory, metal, etc., used for ornament, or for painting pictures upon, as a dish, plate, slab, etc., hung upon a wall; also, a smaller decoration worn by a person, such as a brooch.
  2. A piece of flat metal with writing on it, attached to a building, monument, or other structure to remind people of a person or an event.
  3. A small card representing an amount of money, used for betting in casinos; a sort of gaming chip.
  4. A clearing in a bacterial lawn caused by a virus.
  5. In the Hornbostel–Sachs classification system: any flat, thin musical instrument.
  6. A broad patch of abnormal tissue distinguishable from surrounding tissue, especially a broad papule on the skin.
  7. An abnormal accumulation of material in or on an organ of the body, often associated with disease.

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