Cryptic crossword clue
Calibrate in a different way regarding micro-organisms 9

The most common and most likely answer to this crossword clue is the 9 letter word BACTERIAL

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "regarding micro-organisms" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case regarding micro-organisms = bacterial.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does BACTERIAL mean?

BACTERIAL adjective
  1. Of, relating to, or caused by bacteria.

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