The most common and most likely answer to this crossword clue is the 7 letter word DERANGE
I've seen this crossword clue in The Daily Telegraph
D
E
R
A
N
G
E
More clues leading to the result DERANGE
- Return of Communist fury with Russia's leader put out, upset
- Confuse reigning monarch in endless peril
- Disorder puts part of US hospital in no end of peril
- Disorder resulting from exploding grenade
- Send mad Commie back, row initially avoided
- Send insane, angered terribly
- Throw into confusion, exploding grenade
- Disorder casts monarch into endless peril
- Make insane anagram of four other solutions
- Exploding grenade creates disorder
Buddy explains!
The straight part
We know that "upset" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case upset = derange.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DERANGE mean?
DERANGE verb- (chiefly passive) To cause (someone) to go insane or become deranged.
- To cause disorder in (something); to distort from its ideal state.
- To disrupt somebody's plans, to inconvenience someone; derail.