Cryptic crossword clue
Calmly suggest removing contents to get sac 4

The most common and most likely answer to this crossword clue is the 4 letter word CYST

I've seen this crossword clue in The Daily Telegraph
C
Y
S
T


Buddy explains!

The straight part
We know that "sac" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sac = cyst.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CYST mean?

CYST noun
  1. A pouch or sac without opening, usually membranous and containing morbid matter, which develops in one of the natural cavities or in the substance of an organ.
  2. Of or pertaining to the urinary bladder or gall bladder (in compounds).

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