The most common and most likely answer to this crossword clue is the 4 letter word CYST
I've seen this crossword clue in The Daily Telegraph
C
Y
S
T
More clues leading to the result CYST
- Pouch, conveniently, sat empty
- Stuff from pharmacy sterilised liquid-filled cavity
- Growth: modest boozer has pair separately excised
- Blister? Cyclist needs a hundred and fifty one less
- Perhaps boil some spicy stew
- Bag from fringes of Carnaby Street
- Growth of Percy’s todger
- Can you see the beginnings of growth?
- Biological liquid container kept in pharmacy store
- Bladder and hearts lost in city street
Buddy explains!

The straight part
We know that "sac" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sac = cyst.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CYST mean?
CYST noun- A pouch or sac without opening, usually membranous and containing morbid matter, which develops in one of the natural cavities or in the substance of an organ.
- Of or pertaining to the urinary bladder or gall bladder (in compounds).