Cryptic crossword clue
Can former nurse let go? 6

The most common and most likely answer to this crossword clue is the 6 letter word LOOSEN

I've seen this crossword clue in The Times
L
O
O
S
E
N


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The straight part
We know that "let go" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case let go = loosen.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does LOOSEN mean?

LOOSEN verb
  1. To make loose.
  2. To become loose.
  3. To disengage (a device that restrains).
  4. To become unfastened or undone.
  5. To free from restraint; to set at liberty.
  6. To relieve (the bowels) from constipation; to promote defecation.
  7. To create a breach or rift between (two parties).
  8. To sail away (from the shore).

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