The most common and most likely answer to this crossword clue is the 6 letter word LOCKUP
L
O
C
K
U
P
Buddy explains!

The straight part
We know that "Can" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case can = lockup.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does LOCKUP mean?
LOCKUP noun- A jail cell, or a period of incarceration.
- A storage unit with a door secured by a padlock or deadbolt; a garage
- A device for locking type into position for printing.
- (by extension) A fixed layout involving one or more logos and possibly related text.