The most common and most likely answer to this crossword clue is the 5 letter word ADEEM
A
D
E
E
M
Buddy explains!
The straight part
We know that "Cancel legacy, say, by destruction" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cancel legacy, say, by destruction = adeem.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.