Cryptic crossword clue
Canine? Come again! 5

The most common and most likely answer to this crossword clue is the 5 letter word RECUR

I've seen this crossword clue in Independent
R
E
C
U
R


Buddy explains!

The straight part
We know that "come again" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case come again = recur.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RECUR mean?

RECUR verb
  1. To have recourse (to) someone or something for assistance, support etc.
  2. To happen again.
  3. To recurse.

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