The most common and most likely answer to this crossword clue is the 6 letter word ASTUTE
I've seen this crossword clue in The Times
A
S
T
U
T
E
More clues leading to the result ASTUTE
- Savvy, like student avoiding second drug
- Wily like the Native American in Colorado
- Shrewd piecework in HQ, billions spent
- Wily players caught out by Native American in Colorado
- Wise to have statue moved
- Perceptive, like trade union leaders in the eighties
- Shrewd, like student giving up English once
- Canny as boy king, Egyptian leader
- Shrewd expression of disapproval, entering turbulent sea
- In the role of an old king, Canute ultimately perceptive
Buddy explains!

The straight part
We know that "Canny" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case canny = astute.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ASTUTE mean?
ASTUTE adjective- Quickly and critically discerning.
- Shrewd or crafty.