The most common and most likely answer to this crossword clue is the 10 letter word STREETWISE
I've seen this crossword clue in Independent
S
T
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E
E
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E
More clues leading to the result STREETWISE
- Canny, by the way?
- Wily American actress has time for gentle old comedian
- Cynical in respect of Downing, for one
- Canny wee sister craftily hides joint
- US right wing tweeter is sadly familiar with our ways?
- Wily setter, cooking with sage
- Were tests designed to keep one familiar with urban life?
- Savvy old comedian following Whitehall, say
- Shrewd setter is, we suspect
- Savvy, like London cabbies?
Buddy explains!

The straight part
We know that "Canny" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case canny = streetwise.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does STREETWISE mean?
STREETWISE adjective- Having the necessary knack, personality and instinct for survival in rough, urban environments.
- Possessing a style that embodies the life and microculture located within urban settings, typically in the States.