The most common and most likely answer to this crossword clue is the 2 plus 3 letter word AT BAY
A
T
B
A
Y
More clues leading to the result AT BAY
Buddy explains!
The straight part
We know that "Can't escape from" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case can't escape from = at bay.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.