Cryptic crossword clue
Caper about, leg bone’s blood group being altered by drug 10

The most common and most likely answer to this crossword clue is the 10 letter word ANTIBIOTIC

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "drug" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case drug = antibiotic.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ANTIBIOTIC mean?

ANTIBIOTIC noun
  1. Any substance that can destroy or inhibit the growth of bacteria and similar microorganisms, generally transported by the lymphatic system.
ANTIBIOTIC adjective
  1. (pharmaceutical effect) Of or relating to antibiotics.
  2. Of or relating to the theory that extraterrestrial life does not exist.

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