Cryptic crossword clue
Careless sister, heading off, runs into street 6

The most common and most likely answer to this crossword clue is the 6 letter word UNWARY

I've seen this crossword clue in Independent
U
N
W
A
R
Y

Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does UNWARY mean?

UNWARY adjective
  1. Lacking caution as a result of naïveté or inexperience
  2. Unprepared; not watchful

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