The most common and most likely answer to this crossword clue is the 8 plus 4 letter word BUSINESS CASE
B
U
S
I
N
E
S
S
C
A
S
E
More clues leading to the result BUSINESS CASE
Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.