Cryptic crossword clue
Casual agreement to hold career back leads to destitution 6

The most common and most likely answer to this crossword clue is the 6 letter word PENURY

I've seen this crossword clue in The Guardian
P
E
N
U
R
Y

Buddy explains!

The straight part
We know that "destitution" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case destitution = penury.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PENURY mean?

PENURY noun
  1. Extreme want; poverty; destitution.
  2. A lack of something; a dearth.

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