The most common and most likely answer to this crossword clue is the 1 plus 4 plus 3 plus 2 plus 5 letter word A FISH OUT OF WATER
I've seen this crossword clue in The Times
A
F
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S
H
O
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T
O
F
W
A
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R
More clues leading to the result A FISH OUT OF WATER
- Catch a misfit
- One who’s uncomfortable, absentee from school perhaps
- Catch this misfit?
- One in unfamiliar surroundings, as 21 5?
- Someone ill at ease, a type that’s got hooked?
- Maybe, bleak old tutor a few disrupted is one unsuited to situation
- Criminal oafs without fear getting one in an uncomfortable situation
- Someone not at home saw a fortieth UFO — possibly!
- Perhaps flounder on deck? I’m uncomfortable in this situation
- Flounder — when caught out of place?
Buddy explains!

The straight part
We know that "misfit" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case misfit = a fish out of water.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.