Cryptic crossword clue
Caterpillar: type found in southwest or Middlesex, principally 8

The most common and most likely answer to this crossword clue is the 8 letter word SILKWORM

I've seen this crossword clue in The Times
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Buddy explains!

The straight part
We know that "Caterpillar" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case caterpillar = silkworm.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SILKWORM mean?

SILKWORM noun
  1. Any of various caterpillars of moths that produce silk cocoons, especially Bombyx mori, the source of most commercial silk.

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