The most common and most likely answer to this crossword clue is the 10 letter word UNPUNCTUAL
I've seen this crossword clue in The Times
U
N
P
U
N
C
T
U
A
L
Buddy explains!
The straight part
We know that "with no respect for time" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case with no respect for time = unpunctual.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does UNPUNCTUAL mean?
UNPUNCTUAL adjective- Not punctual.