Cryptic crossword clue
Cause followed by friend from time to time 12

The most common and most likely answer to this crossword clue is the 12 letter word OCCASIONALLY

I've seen this crossword clue in The Daily Telegraph
O
C
C
A
S
I
O
N
A
L
L
Y

Buddy explains!

The straight part
We know that "from time to time" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case from time to time = occasionally.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OCCASIONALLY mean?

OCCASIONALLY adverb
  1. On the occasion of something else happening; incidentally, by the way.
  2. From time to time; sometimes; at relatively infrequent intervals.
  3. By chance; accidentally.

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