The most common and most likely answer to this crossword clue is the 4 plus 3 plus 1 plus 3 plus 4 letter word GIVE ONE A BAD TIME
I've seen this crossword clue in The Guardian
G
I
V
E
O
N
E
A
B
A
D
T
I
M
E
Buddy explains!
The straight part
We know that "Cause somebody hassle" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cause somebody hassle = give one a bad time.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.