Cryptic crossword clue
Cause to see red, initially, amber and green in new combination 6

The most common and most likely answer to this crossword clue is the 6 letter word ENRAGE

E
N
R
A
G
E


Buddy explains!

The straight part
We know that "Cause to see red" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cause to see red = enrage.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ENRAGE mean?

ENRAGE verb
  1. To fill with rage; to provoke to frenzy or madness; to make furious.

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