Cryptic crossword clue
Cell deaths topped small number Puck’s got cross about 8

The most common and most likely answer to this crossword clue is the 8 letter word NECROSIS

I've seen this crossword clue in The Guardian
N
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Buddy explains!

The straight part
We know that "Cell deaths" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cell deaths = necrosis.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NECROSIS mean?

NECROSIS noun
  1. The localized death of cells or tissues through injury, disease, or the interruption of blood supply.

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