Cryptic crossword clue
Centenarian leader and topless coquette don’t do it any more! 5

The most common and most likely answer to this crossword clue is the 5 letter word CEASE

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "don’t do it any more!" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case don’t do it any more! = cease.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CEASE mean?

CEASE noun
  1. Cessation; extinction (see without cease).
CEASE verb
  1. To stop.
  2. To stop doing (something).
  3. To be wanting; to fail; to pass away.

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