The most common and most likely answer to this crossword clue is the 5 letter word CEASE
I've seen this crossword clue in Independent
C
E
A
S
E
More clues leading to the result CEASE
- Cold comfort in end
- Stop drug being injected into patient
- . End trial that’s gobbling up energy
- Centenarian leader and topless coquette don’t do it any more!
- End case about Spain
- Stop giving cold comfort
- Stop Conservative having peace
- Out of gas, car is parked by rest stop
- Stop legal action to arrest Earl
- Stop patient eating last of cheese
Buddy explains!

The straight part
We know that "don’t do it any more!" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case don’t do it any more! = cease.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CEASE mean?
CEASE noun- Cessation; extinction (see without cease).
- To stop.
- To stop doing (something).
- To be wanting; to fail; to pass away.