Cryptic crossword clue
Certain philosophers revolutionised science with big apple 6

The most common and most likely answer to this crossword clue is the 6 letter word CYNICS

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The cryptic/wordplay part
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What does CYNICS mean?

CYNICS noun
  1. A person who believes that all people are motivated by selfishness.
  2. A person whose outlook is scornfully negative.

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