The most common and most likely answer to this crossword clue is the 7 letter word CONTEND
I've seen this crossword clue in The Guardian
C
O
N
T
E
N
D
More clues leading to the result CONTEND
- Claim to know nurse
- Challenge something said against nurse
- Tory minister to argue earnestly
- Struggle for Tory leader after deception leads to downfall
- Be inclined to follow Tory challenge
- Hold check, primarily on nurse
- Challenge Tory over care
- Lean towards supporting a prisoner for a challenge
- Tory minister in struggle
- English ex-boxer briefly at perimeter in neighbourhood fight
Buddy explains!

The straight part
We know that "Challenge something said" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case challenge something said = contend.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CONTEND mean?
CONTEND verb- To strive in opposition; to contest; to dispute; to vie; to quarrel; to fight.
- To struggle or exert oneself to obtain or retain possession of, or to defend.
- To strive in debate; to engage in discussion; to dispute; to argue.
- To believe (something is reasonable) and argue (for it); to advocate.