The most common and most likely answer to this crossword clue is the 9 letter word MENOPAUSE
I've seen this crossword clue in The Guardian
M
E
N
O
P
A
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More clues leading to the result MENOPAUSE
Buddy explains!
The straight part
We know that "Change" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case change = menopause.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MENOPAUSE mean?
MENOPAUSE noun- The period in a woman's life when menstruation becomes irregular and less frequent before eventually stopping altogether, usually accompanied by a range of unpleasant symptoms; the period spanning perimenopause up to postmenopause.
- The final menstrual period of a woman after which ovulation no longer occurs.